tetradecadienedioate (c14:2-dc)* to stearate (18:0)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.266
Position:
102075479
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-12.991
Reference Allele:
G
-log10(P):
-87.178
MAF:
0.175
Beta (Num):
-0.169
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Dicarboxylate Pathway4[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis5[1]

Ratio Explanation:

The ratio of tetradecadienedioate to stearate may reflect the balance between fatty acid synthesis and its subsequent desaturation and oxidation, influenced by SCD activity.6[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SCD activity can alter the balance of saturated to unsaturated fatty acids, a state implicated in atherosclerosis, dyslipidemia, and myocardial infarction.2[1], 8[2] This aligns with the observed cardiovascular phenotypes, suggesting that genetic variants affecting SCD function are causally linked to heart disease.

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data