tetradecadienedioate (c14:2-dc)* to palmitate (16:0)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.215
Position:
102075479
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-10.963
Reference Allele:
G
-log10(P):
-62.725
MAF:
0.175
Beta (Num):
-0.169
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.046
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Dicarboxylate metabolism

Denominator Metabolite Explanation:

Fatty acid biosynthesis, beta-Oxidation.4[1], 5[2]

Ratio Explanation:

The ratio of tetradecadienedioate to palmitate may reflect the activity of ACOT enzymes in processing different fatty acid substrates.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

ACOT gene variants may alter fatty acid metabolism, influencing the availability of specific fatty acids like palmitate, which has been linked to lipotoxicity and cardiovascular disease.6[1], 7[2], 8[3] This altered lipid profile could contribute to the development of atherosclerosis and hypercholesterolemia.

Phenotype Driver:

Gene-centric:ACOT2/ACOT4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data