tetradecadienedioate (c14:2-dc)* to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.190
Position:
25802083
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
-15.215
Reference Allele:
T
-log10(P):
-118.696
MAF:
0.444
Beta (Num):
-0.026
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.164
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Dicarboxylic acid metabolism, fatty acid omega-oxidation.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Dicarboxylic acid metabolism, fatty acid omega-oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

An elevated ratio may indicate altered peroxisomal beta-oxidation of dicarboxylic acids, potentially influenced by SLC17A4's role in organic anion transport.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's role in transporting organic anions like urate provides a direct link to serum uric acid levels and MCHC.3[1], 10[2], 11[3] Altered dicarboxylic acid metabolism, reflected in the ratio, may influence hematopoiesis and erythrocyte indices.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data