pregnenetriol sulfate* to DHEAS

Numerator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
7
Beta (Ratio):
0.455
Position:
99075038
SE (Ratio):
0.026
Effect Allele:
C
Z-score (Ratio):
17.166
Reference Allele:
T
-log10(P):
-150.408
MAF:
0.034
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.035
Beta (Den):
-0.423
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Steroid biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects the balance between two sulfated adrenal steroids. An altered ratio may indicate shifts in steroidogenesis or sulfotransferase activity.4[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic factors, such as ZNF394 or GAL3ST4, may alter steroid metabolism, reflected by the pregnenetriol sulfate to DHEAS ratio. This hormonal imbalance could influence inflammatory (CRP, WBC) and metabolic (BMI, Uric Acid) phenotypes, as steroid hormones are known regulators of these processes.1[1], 10[2]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data