pregnenetriol sulfate* to androstenediol (3beta,17beta) disulfate (1)

Numerator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (1)
Metabolite Accession: GCST90199842
Name: androstenediol (3beta,17beta) disulfate (1)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.347
Position:
99075038
SE (Ratio):
0.032
Effect Allele:
C
Z-score (Ratio):
10.973
Reference Allele:
T
-log10(P):
-62.832
MAF:
0.034
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.035
Beta (Den):
-0.316
SE (Den):
0.038
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Steroid sulfation.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism, Steroid sulfation.5[1], 6[2]

Ratio Explanation:

The ratio reflects the balance between pregnenetriol sulfate and androstenediol disulfate, sulfated steroids potentially regulated by the transcription factor ZNF394.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

ZNF394, as a transcription factor, may regulate steroid hormone pathways, impacting the levels of sulfated steroids. This hormonal alteration could systemically influence inflammatory markers (CRP, WBC), metabolic traits (BMI, Uric acid), and growth (Height).

Phenotype Driver:

Gene-centric:ZNF394

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data