pregnenetriol sulfate* to 21-hydroxypregnenolone disulfate

Numerator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Denominator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Associated Genomic Regions

Region: rs57025390

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.182
Position:
47412477
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
11.353
Reference Allele:
C
-log10(P):
-67.110
MAF:
0.123
Beta (Num):
-0.002
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.184
SE (Den):
0.022
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

Region: rs3732218

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.203
Position:
234627304
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-10.803
Reference Allele:
G
-log10(P):
-60.962
MAF:
0.082
Beta (Num):
-0.187
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.016
SE (Den):
0.026
No CNV overlap
rQTL cluster:
136
Reaction Distance:
NA
Closest Genes:
UGT1A10 UGT1A5 UGT1A8 UGT1A6 UGT1A7

Region: rs2762353

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.157
Position:
25794431
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-14.901
Reference Allele:
G
-log10(P):
-113.955
MAF:
0.445
Beta (Num):
0.004
Novel Locus:
No
SE (Num):
0.013
Beta (Den):
0.161
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Steroid Sulfation6[1], 7[2]

Denominator Metabolite Explanation:

Steroidogenesis, Corticosteroid biosynthesis8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects the balance between two adrenal steroid hormone precursors. Altered UGT1A8 activity could indirectly affect steroid sulfation or clearance, influencing this balance.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in UGT1A8 are linked to altered bilirubin metabolism and hematological traits like MCH and hemoglobin.4[1], 11[2], 12[3], 13[4] The association with this steroid ratio suggests the UGT1A8 variant's pleiotropic effects may influence both steroid and bilirubin conjugation, impacting these phenotypes.

Phenotype Driver:

Gene-centric:UGT1A8

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data