pregnenetriol sulfate* to androstenediol (3alpha, 17alpha) monosulfate (3)

Numerator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Denominator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.872
Position:
99075038
SE (Ratio):
0.034
Effect Allele:
C
Z-score (Ratio):
25.945
Reference Allele:
T
-log10(P):
-340.051
MAF:
0.034
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.035
Beta (Den):
-0.840
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis.8[1], 9[2]

Ratio Explanation:

This ratio likely reflects the activity of androgen metabolism, where UGT2B17 alters the pool of androstenediol available for sulfation versus glucuronidation.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in UGT2B17, an androgen metabolizing enzyme, likely alters the balance of steroid hormones reflected in the ratio. These hormonal changes are known to influence lipid metabolism, contributing to phenotypes like dyslipidemia and altered LDL/HDL cholesterol.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data