pregnenetriol sulfate* to 16a-hydroxy dhea 3-sulfate

Numerator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Denominator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.013
Position:
99075038
SE (Ratio):
0.035
Effect Allele:
C
Z-score (Ratio):
-28.587
Reference Allele:
T
-log10(P):
-412.180
MAF:
0.034
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.035
Beta (Den):
1.044
SE (Den):
0.039
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Pregnenolone metabolism.9[1], 10[2], 11[3]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.12[1], 13[2], 14[3]

Ratio Explanation:

This ratio may reflect CYP2C8 16-alpha hydroxylase activity, where decreased function could lower the production of 16a-hydroxy DHEA 3-sulfate, thus increasing the ratio.4[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in CYP2C8 alters its metabolic activity towards steroids, reflected by the ratio, and fatty acids, which mediate inflammation, influencing phenotypes like C-reactive protein, BMI, and uric acid.4[1], 15[2], 16[3], 17[4], 18[5]

Phenotype Driver:

Gene-centric:CYP2C8

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data