pregnenetriol sulfate* to androstenediol (3beta,17beta) monosulfate (1)

Numerator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (1)
Metabolite Accession: GCST90199872
Name: androstenediol (3beta,17beta) monosulfate (1)
Hmdb Id: HMDB0240429
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.413
Position:
99075038
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
14.049
Reference Allele:
T
-log10(P):
-101.558
MAF:
0.034
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.035
Beta (Den):
-0.382
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Sulfated steroid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Steroidogenesis, Sulfated steroid metabolism.4[1], 5[2]

Ratio Explanation:

The ratio reflects the relative sulfation of pregnenetriol and androstenediol, likely influenced by a steroid sulfotransferase gene (e.g., SULT2A1) near GAL3ST4.1[1], 7[2], 3[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation near GAL3ST4 likely alters steroid sulfotransferase activity, changing the pregnenetriol sulfate to androstenediol sulfate ratio. This altered steroid hormone balance plausibly affects body mass, height, and inflammatory markers (CRP, WBC, UA).1[1], 8[2]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data