hydroxypalmitoyl sphingomyelin (d18:1/16:0(oh))** to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Metabolite Accession: GCST90200243
Name: hydroxypalmitoyl sphingomyelin (d18:1/16:0(oh))**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.218
Position:
116648917
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
-8.240
Reference Allele:
C
-log10(P):
-36.295
MAF:
0.131
Beta (Num):
-0.110
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
0.108
SE (Den):
0.022
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.

Ratio Explanation:

The ratio reflects the balance between sphingolipid and glycerophospholipid metabolism, potentially influenced by apolipoprotein A1's role in lipid transport and metabolism.1[1], 2[2], 3[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced APOA1 function, indicated by pQTL colocalization, likely alters the balance of hydroxypalmitoyl sphingomyelin and stearoyl-linoleoyl-GPI, contributing to dyslipidemia and increasing the risk for atherosclerosis, hypercholesterolemia, and myocardial infarction.1[1], 2[2], 6[3], 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:APOA1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data