hydroxypalmitoyl sphingomyelin (d18:1/16:0(oh))** to 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*

Numerator Metabolite

Metabolite Accession: GCST90200243
Name: hydroxypalmitoyl sphingomyelin (d18:1/16:0(oh))**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.622
Position:
61593816
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
24.721
Reference Allele:
C
-log10(P):
-309.005
MAF:
0.339
Beta (Num):
0.281
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.340
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance between sphingolipid pathways and the FADS-mediated synthesis of arachidonic acid-containing glycerophospholipids, a key process in inflammation.10[1], 11[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the production of arachidonic acid and other pro-inflammatory lipids, influencing the risk for inflammatory and metabolic phenotypes like cholelithiasis, type 2 diabetes, and inflammatory bowel disease.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data