3-hydroxydecanoylcarnitine to laurylcarnitine

Numerator Metabolite

Structure of 3-hydroxydecanoylcarnitine
Metabolite Accession: GCST90200246
Name: 3-hydroxydecanoylcarnitine
Hmdb Id: HMDB0061636
Super Pathway: NA
Sub Pathway: NA
Inchikey: VCRSQDIROUELAR

Denominator Metabolite

Structure of laurylcarnitine (c12)
Metabolite Accession: GCST90199750
Name: laurylcarnitine (c12)
Hmdb Id: HMDB000225
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUJLYHJROOYKRA

Associated Genomic Regions

Region: rs17843966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
4
Beta (Ratio):
0.132
Position:
159629814
SE (Ratio):
0.011
Effect Allele:
C
Z-score (Ratio):
12.371
Reference Allele:
A
-log10(P):
-79.272
MAF:
0.264
Beta (Num):
0.040
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.092
SE (Den):
0.017
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
ETFDH PPID C4orf46 RXFP1 FNIP2

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

The ratio of 3-hydroxydecanoylcarnitine to laurylcarnitine may reflect altered flux through the fatty acid oxidation pathway, potentially influenced by ETFDH function.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data