3-hydroxydecanoylcarnitine to hexanoylglutamine

Numerator Metabolite

Structure of 3-hydroxydecanoylcarnitine
Metabolite Accession: GCST90200246
Name: 3-hydroxydecanoylcarnitine
Hmdb Id: HMDB0061636
Super Pathway: NA
Sub Pathway: NA
Inchikey: VCRSQDIROUELAR

Denominator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.344
Position:
25809069
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
22.030
Reference Allele:
G
-log10(P):
-245.982
MAF:
0.444
Beta (Num):
0.027
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.318
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2]

Denominator Metabolite Explanation:

Acyl-amino acid metabolism, likely for fatty acid detoxification.9[1], 10[2]

Ratio Explanation:

The ratio likely reflects a balance between mitochondrial fatty acid oxidation (numerator) and alternative fatty acid metabolism/detoxification (denominator), but a direct link is not established.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's primary function as a urate transporter directly explains the association with serum uric acid and creatinine, which can secondarily influence hematological indices.1[1], 11[2], 12[3], 13[4], 14[5], 15[6]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data