3-hydroxydecanoylcarnitine to 3-hydroxyoctanoylcarnitine (1)

Numerator Metabolite

Structure of 3-hydroxydecanoylcarnitine
Metabolite Accession: GCST90200246
Name: 3-hydroxydecanoylcarnitine
Hmdb Id: HMDB0061636
Super Pathway: NA
Sub Pathway: NA
Inchikey: VCRSQDIROUELAR

Denominator Metabolite

Structure of 3-hydroxyoctanoylcarnitine (1)
Metabolite Accession: GCST90200272
Name: 3-hydroxyoctanoylcarnitine (1)
Hmdb Id: HMDB0061634
Super Pathway: NA
Sub Pathway: NA
Inchikey: LUBMSOHGUAAXAM

Associated Genomic Regions

Region: rs60782127

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
16
Beta (Ratio):
0.215
Position:
16142079
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
8.487
Reference Allele:
G
-log10(P):
-38.395
MAF:
0.011
Beta (Num):
-0.221
Novel Locus:
Yes ✔️
SE (Num):
0.072
Beta (Den):
-0.436
SE (Den):
0.072
No CNV overlap
rQTL cluster:
173
Reaction Distance:
NA
Closest Genes:
ABCC1 ABCC6 FOPNL NOMO3 MYH11

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2], 10[3]

Ratio Explanation:

This ratio reflects the relative flux of C10 versus C8 3-hydroxyacylcarnitines through the fatty acid oxidation pathway, potentially influenced by ABCC1 transporter activity.4[1], 11[2], 12[3], 13[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

A missense variant in the ABCC1 transporter gene is associated with altered levels of fatty acid oxidation intermediates.4[1] This altered energy metabolism may plausibly influence complex developmental processes like growth, leading to the observed statistical association with height.14[2], 15[3]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data