cis 3,4-methyleneheptanoate to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Metabolite Accession: GCST90200248
Name: cis-3,4-methyleneheptanoate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.180
Position:
21343833
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-8.126
Reference Allele:
A
-log10(P):
-35.352
MAF:
0.156
Beta (Num):
-0.067
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.113
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.6[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.7[1], 8[2]

Ratio Explanation:

The ratio likely reflects altered hepatic uptake by SLCO1B1, where reduced function decreases linolenoylcarnitine clearance, while the numerator may be an unassociated xenobiotic.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 transporter function, indicated by the elevated ratio, alters lipid and bilirubin levels, which are factors associated with coronary atherosclerosis and the observed hematological and metabolic phenotypes.1[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data