cis 3,4-methyleneheptanoate to cis-3,4-methyleneheptanoylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90200248
Name: cis-3,4-methyleneheptanoate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200266
Name: cis-3,4-methyleneheptanoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2279501

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.102
Position:
151917393
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
-10.443
Reference Allele:
C
-log10(P):
-57.107
MAF:
0.402
Beta (Num):
-0.015
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.087
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.6[1], 7[2]

Ratio Explanation:

This ratio may reflect THEM4 thioesterase activity, which hydrolyzes the acyl-CoA precursor of both metabolites, thereby influencing their relative abundance in fatty acid metabolism.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data