branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to docosatrienoate (22:3n3)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.302
Position:
61595564
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-14.790
Reference Allele:
C
-log10(P):
-112.293
MAF:
0.179
Beta (Num):
-0.023
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.278
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (n-3) biosynthesis.4[1], 5[2]

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity; decreased enzyme function leads to lower levels of the denominator (22:3n3), a downstream product, thereby increasing the ratio.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the synthesis of polyunsaturated fatty acids, which are precursors to inflammatory mediators.6[1], 7[2] This dysregulation can affect the balance of pro- and anti-inflammatory molecules, contributing to inflammatory conditions like asthma, sinusitis, and dermatitis.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data