branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to hexadecanedioate (c16-dc)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.129
Position:
15979744
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
8.121
Reference Allele:
C
-log10(P):
-35.307
MAF:
0.296
Beta (Num):
0.034
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.095
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.2[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.5[1], 6[2]

Ratio Explanation:

An elevated ratio suggests a shift in fatty acid metabolism, where the degradation of 12:1 fatty acids might be altered relative to hexadecanedioate production, potentially influenced by CYP4F2 activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The CYP4F2 variant, by altering fatty acid metabolism, contributes to dyslipidemia (e.g., elevated triglycerides) and an inflammatory state.7[1], 8[2], 9[3], 10[4] This dysregulation is associated with the development of coronary atherosclerosis and ischaemic heart disease.7[5], 11[6], 12[7], 13[8]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data