deoxycholic acid 12-sulfate* to 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**

Numerator Metabolite

Metabolite Accession: GCST90200250
Name: deoxycholic acid 12-sulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Metabolite Accession: GCST90200172
Name: 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Hmdb Id: HMDB0061643
Super Pathway: NA
Sub Pathway: NA
Inchikey: RIJDKRLRDVBUHJ

Associated Genomic Regions

Region: rs112997117

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.488
Position:
101619779
SE (Ratio):
0.047
Effect Allele:
C
Z-score (Ratio):
-10.352
Reference Allele:
T
-log10(P):
-56.154
MAF:
0.057
Beta (Num):
-0.278
Novel Locus:
No
SE (Num):
0.035
Beta (Den):
0.210
SE (Den):
0.032
No CNV overlap
rQTL cluster:
68
Reaction Distance:
NA
Closest Genes:
ABCC2 DNMBP CUTC COX15 ENTPD7

LLM Analysis

Numerator Metabolite Explanation:

Secondary bile acid metabolism, Sulfation.6[1], 7[2]

Denominator Metabolite Explanation:

Furanoid fatty acid metabolism, Uremic toxin pathway.8[1], 9[2]

Ratio Explanation:

The ratio reflects altered hepatic clearance by ABCC2; reduced function decreases deoxycholic acid 12-sulfate export, while 3-CMPFP levels may be independently regulated or affected by renal function.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired ABCC2 function due to genetic variants likely reduces the biliary excretion of sulfated bile acids and other organic anions, contributing to elevated liver enzymes (GGT, AST, ALT), which are markers of liver stress or damage.1[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:ABCC2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data