vanillic acid glycine to n6-carbamoylthreonyladenosine

Numerator Metabolite

Structure of vanillic acid glycine
Metabolite Accession: GCST90200253
Name: vanillic acid glycine
Hmdb Id: HMDB0060026
Super Pathway: NA
Sub Pathway: NA
Inchikey: LOODYTDRRBLQNH

Denominator Metabolite

Structure of n6-carbamoylthreonyladenosine
Metabolite Accession: GCST90199762
Name: n6-carbamoylthreonyladenosine
Hmdb Id: HMDB0041623
Super Pathway: NA
Sub Pathway: NA
Inchikey: GYCVHQYQICRFAX

Associated Genomic Regions

Region: rs556339

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.217
Position:
25870745
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
-8.945
Reference Allele:
C
-log10(P):
-42.435
MAF:
0.252
Beta (Num):
-0.111
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.106
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A3 SLC17A1 SLC17A2 SLC17A4 TRIM38

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Glycine conjugation.6[1], 7[2]

Denominator Metabolite Explanation:

tRNA modification, Purine metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio likely reflects altered renal transport by SLC17A3, affecting clearance of both a modified purine (denominator) and a xenobiotic conjugate (numerator).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A3 variant alters renal transport, directly impacting serum uric acid, creatinine, and hematocrit, which are key phenotypes.4[1], 11[2], 12[3], 13[4] This altered renal function secondarily associates with metabolic phenotypes like triglycerides and pulse pressure, linking the gene to broader cardiometabolic health.14[5], 15[6]

Phenotype Driver:

Gene-centric:SLC17A3

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data