vanillic acid glycine to thymol sulfate

Numerator Metabolite

Structure of vanillic acid glycine
Metabolite Accession: GCST90200253
Name: vanillic acid glycine
Hmdb Id: HMDB0060026
Super Pathway: NA
Sub Pathway: NA
Inchikey: LOODYTDRRBLQNH

Denominator Metabolite

Structure of thymol sulfate
Metabolite Accession: GCST90199827
Name: thymol sulfate
Hmdb Id: HMDB0062720
Super Pathway: NA
Sub Pathway: NA
Inchikey: NODSEPOUFZPJEQ

Associated Genomic Regions

Region: rs12212049

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.222
Position:
25759066
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
9.666
Reference Allele:
G
-log10(P):
-49.222
MAF:
0.415
Beta (Num):
0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.110
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A4 SLC17A1 HIST1H2BA HIST1H2AA SCGN

LLM Analysis

Numerator Metabolite Explanation:

Glycine conjugation of xenobiotics, Benzoic acid metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Xenobiotic metabolism, sulfation pathway.9[1], 10[2]

Ratio Explanation:

This ratio may reflect altered transport activity by SLC17A4, potentially affecting the clearance of both vanillic acid glycine (anionic metabolite) and thymol sulfate.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene, a known urate transporter, likely influences the phenotype.4[1], 5[2], 11[3] Altered SLC17A4 function due to the missense variant could impact uric acid transport, leading to changes in MCHC, Hb, and sCr, which are associated with renal function and hematological parameters often linked to urate levels.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data