vanillic acid glycine to 4-allylphenol sulfate

Numerator Metabolite

Structure of vanillic acid glycine
Metabolite Accession: GCST90200253
Name: vanillic acid glycine
Hmdb Id: HMDB0060026
Super Pathway: NA
Sub Pathway: NA
Inchikey: LOODYTDRRBLQNH

Denominator Metabolite

Structure of 4-allylphenol sulfate
Metabolite Accession: GCST90199847
Name: 4-allylphenol sulfate
Hmdb Id: HMDB0170765
Super Pathway: NA
Sub Pathway: NA
Inchikey: KFDHKOFCRYUXLA

Associated Genomic Regions

Region: rs1165191

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.238
Position:
25847847
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
-9.431
Reference Allele:
A
-log10(P):
-46.957
MAF:
0.246
Beta (Num):
-0.112
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.127
SE (Den):
0.018
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A3 SLC17A1 SLC17A2 SLC17A4 TRIM38

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, glycine conjugation.7[1], 8[2]

Denominator Metabolite Explanation:

Xenobiotic metabolism, sulfation.9[1], 10[2], 11[3]

Ratio Explanation:

The ratio likely reflects activity of different xenobiotic detoxification pathways, potentially influenced by SLC17A3's broad role in transporting various organic anions.4[1], 5[2], 12[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A3 function is known to impact renal urate transport, directly causing changes in uric acid levels.2[1], 13[2], 14[3] The ratio of these xenobiotic metabolites may reflect the altered transporter activity associated with the uric acid phenotype.

Phenotype Driver:

Gene-centric:SLC17A3

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data