vanillic acid glycine to ferulic acid 4-sulfate

Numerator Metabolite

Structure of vanillic acid glycine
Metabolite Accession: GCST90200253
Name: vanillic acid glycine
Hmdb Id: HMDB0060026
Super Pathway: NA
Sub Pathway: NA
Inchikey: LOODYTDRRBLQNH

Denominator Metabolite

Structure of ferulic acid 4-sulfate
Metabolite Accession: GCST90199955
Name: ferulic acid 4-sulfate
Hmdb Id: HMDB0029200
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZPATWACAAOHTJ

Associated Genomic Regions

Region: rs1165196

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.411
Position:
25813150
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
22.195
Reference Allele:
A
-log10(P):
-249.637
MAF:
0.447
Beta (Num):
0.111
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.300
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism

Denominator Metabolite Explanation:

Sulfate conjugation

Ratio Explanation:

The ratio may reflect altered transport activity by SLC17A4, potentially influencing the disposition of xenobiotic-derived metabolites and impacting urate levels.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC17A4 likely alters its transport function, affecting uric acid levels and subsequently influencing hematological traits like MCH, MCV, MCHC, hemoglobin, and hematocrit, as well as creatinine and HbA1c.5[1], 6[2], 7[3], 8[4], 9[5], 10[6]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data