vanillic acid glycine to n-acetylkynurenine (2)

Numerator Metabolite

Structure of vanillic acid glycine
Metabolite Accession: GCST90200253
Name: vanillic acid glycine
Hmdb Id: HMDB0060026
Super Pathway: NA
Sub Pathway: NA
Inchikey: LOODYTDRRBLQNH

Denominator Metabolite

Structure of n-acetylkynurenine (2)
Metabolite Accession: GCST90200015
Name: n-acetylkynurenine (2)
Hmdb Id: HMDB0240342
Super Pathway: NA
Sub Pathway: NA
Inchikey: PPIMFXHQDQRWGJ

Associated Genomic Regions

Region: rs1165196

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.239
Position:
25813150
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
10.138
Reference Allele:
A
-log10(P):
-53.941
MAF:
0.447
Beta (Num):
0.111
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.128
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Phenylalanine and Tyrosine metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Tryptophan metabolism, Kynurenine pathway.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

The ratio may reflect the balance between xenobiotic detoxification (vanillic acid glycine) and tryptophan catabolism (n-acetylkynurenine), potentially influenced by intestinal transport processes mediated by SLC17A4.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's role as a urate transporter directly links it to serum uric acid levels, a key phenotype.1[1], 4[2], 5[3], 13[4] The hematological phenotypes (MCH, MCV, MCHC, Hb, Ht) may arise from downstream effects of altered urate homeostasis or other transport functions not fully elucidated.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data