vanillic acid glycine to n-acetylleucine

Numerator Metabolite

Structure of vanillic acid glycine
Metabolite Accession: GCST90200253
Name: vanillic acid glycine
Hmdb Id: HMDB0060026
Super Pathway: NA
Sub Pathway: NA
Inchikey: LOODYTDRRBLQNH

Denominator Metabolite

Structure of n-acetylleucine
Metabolite Accession: GCST90200288
Name: n-acetylleucine
Hmdb Id: HMDB0011756
Super Pathway: NA
Sub Pathway: NA
Inchikey: WXNXCEHXYPACJF

Associated Genomic Regions

Region: rs1165196

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.201
Position:
25813150
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
9.252
Reference Allele:
A
-log10(P):
-45.265
MAF:
0.447
Beta (Num):
0.111
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.090
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Glycine conjugation5[1], 6[2]

Denominator Metabolite Explanation:

Leucine metabolism, Protein acetylation7[1], 8[2]

Ratio Explanation:

The ratio may reflect altered transport of organic anions by SLC17A4, potentially influencing the balance between a gut-derived xenobiotic and an amino acid derivative.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene, a urate transporter, likely drives the associated phenotypes.3[1], 9[2] Altered uric acid transport by SLC17A4 variants impacts serum urate levels, which are linked to creatinine and hematological indices like hemoglobin and hematocrit, reflecting kidney function and erythropoiesis.10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data