vanillic acid glycine to n-acetylphenylalanine

Numerator Metabolite

Structure of vanillic acid glycine
Metabolite Accession: GCST90200253
Name: vanillic acid glycine
Hmdb Id: HMDB0060026
Super Pathway: NA
Sub Pathway: NA
Inchikey: LOODYTDRRBLQNH

Denominator Metabolite

Structure of n-acetylphenylalanine
Metabolite Accession: GCST90200677
Name: n-acetylphenylalanine
Hmdb Id: HMDB0000512
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBQJSKKFNMDLON

Associated Genomic Regions

Region: rs1165196

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.258
Position:
25813150
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
12.237
Reference Allele:
A
-log10(P):
-77.604
MAF:
0.447
Beta (Num):
0.111
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.147
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic detoxification, Glycine metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Phenylalanine metabolism, uremic toxin production.8[1], 9[2]

Ratio Explanation:

The ratio may reflect altered renal or intestinal clearance of organic anions, as SLC17A4 transports urate and other anions, potentially influencing n-acetylphenylalanine excretion.3[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 transporter's role in urate excretion likely drives the association with serum uric acid levels.3[1], 5[2] The link to hematological phenotypes like MCH and Hb could be secondary to uric acid's antioxidant properties or its correlation with red blood cell parameters.11[3], 12[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data