n-succinyl-phenylalanine to hexanoylglutamine

Numerator Metabolite

Structure of n-succinyl-phenylalanine
Metabolite Accession: GCST90200262
Name: n-succinyl-phenylalanine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CWAGPBPLOYGROC

Denominator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Associated Genomic Regions

Region: rs2817188

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.682
Position:
25807603
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
28.743
Reference Allele:
G
-log10(P):
-416.658
MAF:
0.466
Beta (Num):
0.364
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.318
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Phenylalanine degradation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Acyl-glutamine metabolism.7[1], 8[2]

Ratio Explanation:

The ratio may reflect altered transport activity by SLC17A4 influencing phenylalanine-derived and fatty-acid-derived metabolite pools, but a direct link is not established.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant likely alters transporter function, affecting urate levels and red blood cell indices. The connection to the metabolite ratio is unclear, but the gene's primary function directly explains the uric acid and hematological phenotypes.3[1], 9[2], 10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data