n-succinyl-phenylalanine to ferulic acid 4-sulfate

Numerator Metabolite

Structure of n-succinyl-phenylalanine
Metabolite Accession: GCST90200262
Name: n-succinyl-phenylalanine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CWAGPBPLOYGROC

Denominator Metabolite

Structure of ferulic acid 4-sulfate
Metabolite Accession: GCST90199955
Name: ferulic acid 4-sulfate
Hmdb Id: HMDB0029200
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZPATWACAAOHTJ

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.665
Position:
25794431
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
29.157
Reference Allele:
G
-log10(P):
-428.654
MAF:
0.466
Beta (Num):
0.364
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.302
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Phenylalanine metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Phenylpropanoid metabolism, sulfation.6[1]

Ratio Explanation:

The ratio may reflect altered intestinal transport by SLC17A4, potentially influencing the availability of phenylalanine for succinylation and the systemic levels of ferulic acid sulfate.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function due to the missense variant likely impacts urate and other substrate transport, leading to the associated phenotypes of altered MCHC, MCH, and serum creatinine.1[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data