(2 or 3)-decenoate (10:1n7 or n8) to cis-4-decenoylcarnitine (c10:1)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of cis-4-decenoylcarnitine (c10:1)
Metabolite Accession: GCST90199880
Name: cis-4-decenoylcarnitine (c10:1)
Hmdb Id: HMDB0013205
Super Pathway: NA
Sub Pathway: NA
Inchikey: GOOOCIIXFLVRAG

Associated Genomic Regions

Region: rs612022

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.202
Position:
4126916
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
12.172
Reference Allele:
G
-log10(P):
-76.805
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.044
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

The ratio of (2/3)-decenoate to cis-4-decenoylcarnitine likely reflects the enzymatic efficiency of ECI2 in the beta-oxidation pathway of C10 unsaturated fatty acids.4[1], 14[2], 13[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between the ECI2-driven metabolic ratio and a clinical outcome cannot be established from the input data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data