(2 or 3)-decenoate (10:1n7 or n8) to n-palmitoylglycine

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.380
Position:
46870761
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-19.739
Reference Allele:
C
-log10(P):
-198.031
MAF:
0.208
Beta (Num):
-0.044
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.336
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism; Beta-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

N-acyl glycine metabolism; Fatty acid amide hydrolysis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect FAAH enzyme efficiency; reduced FAAH function would increase N-palmitoylglycine levels, thereby decreasing the ratio, with an unclear link to decenoate.2[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype information is provided, so no causal link between the genetic factors, the metabolite ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data