(2 or 3)-decenoate (10:1n7 or n8) to arachidonate (20:4n6)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.318
Position:
61593005
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
21.806
Reference Allele:
A
-log10(P):
-241.060
MAF:
0.346
Beta (Num):
0.006
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.312
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.4[1]

Denominator Metabolite Explanation:

PUFA biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS desaturase activity; lower activity decreases the denominator (arachidonate), increasing the ratio and indicating altered long-chain fatty acid synthesis.1[1], 7[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FADS activity, reflected by the ratio, alters arachidonate levels and downstream inflammatory mediators, contributing to phenotypes like cholelithiasis, hypercholesterolemia, and benign colorectal neoplasms.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data