cis-3,4-methyleneheptanoylcarnitine to 3-hydroxylaurate

Numerator Metabolite

Metabolite Accession: GCST90200266
Name: cis-3,4-methyleneheptanoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Associated Genomic Regions

Region: rs2999541

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.210
Position:
151898749
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
9.575
Reference Allele:
C
-log10(P):
-48.334
MAF:
0.374
Beta (Num):
0.102
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, xenobiotic metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Ratio Explanation:

This ratio compares an unusual acylcarnitine, potentially from xenobiotic or gut microbe metabolism, to a standard beta-oxidation intermediate, likely reflecting altered fatty acid oxidation influenced by THEM4.3[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic regulation of THEM4 expression likely alters fatty acid metabolism, reflected in this ratio.7[1], 8[2], 9[3] A causal link to a specific phenotype is not established with the provided information, though the numerator has been associated with Gestational Diabetes Mellitus.10[4]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data