cis-3,4-methyleneheptanoylcarnitine to dodecadienoate (12:2)*

Numerator Metabolite

Metabolite Accession: GCST90200266
Name: cis-3,4-methyleneheptanoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2999541

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.215
Position:
151898749
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
10.424
Reference Allele:
C
-log10(P):
-56.908
MAF:
0.374
Beta (Num):
0.102
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.113
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.8[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.8[1], 9[2], 10[3], 11[4], 12[5]

Ratio Explanation:

An elevated ratio may indicate altered mitochondrial fatty acid beta-oxidation, potentially influenced by THEM4's thioesterase activity on acyl-CoA intermediates.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No established link between the gene, ratio, and a specific phenotype is available.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data