cis-3,4-methyleneheptanoylcarnitine to beta-hydroxyisovalerate

Numerator Metabolite

Metabolite Accession: GCST90200266
Name: cis-3,4-methyleneheptanoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200322
Name: beta-hydroxyisovalerate
Hmdb Id: HMDB0000754
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs3007670

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.208
Position:
151897616
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
9.915
Reference Allele:
G
-log10(P):
-51.683
MAF:
0.375
Beta (Num):
0.102
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.106
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Valine, leucine and isoleucine degradation.5[1]

Ratio Explanation:

The ratio may reflect THEM4's thioesterase activity on a fatty acyl-CoA (numerator) relative to its indirect influence on leucine catabolism (denominator).1[1], 5[2], 6[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data