tetrahydrocortisol glucuronide to androstenediol (3beta,17beta) monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90200267
Name: tetrahydrocortisol glucuronide
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs2900478

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.204
Position:
21368797
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
8.336
Reference Allele:
T
-log10(P):
-37.102
MAF:
0.166
Beta (Num):
0.091
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
-0.113
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Cortisol metabolism, glucuronidation.6[1], 7[2]

Denominator Metabolite Explanation:

Androgen metabolism, steroid sulfation.8[1], 9[2]

Ratio Explanation:

The ratio likely reflects altered hepatic clearance; reduced SLCO1B1 function can increase circulating androstenediol sulfate, thus affecting this specific steroid hormone metabolite ratio.4[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLCO1B1 function from genetic variants reduces hepatic uptake of uric acid and bilirubin, directly elevating their serum levels and causing gout and hyperbilirubinemia (increased TBil).11[1], 12[2], 13[3], 14[4] The altered metabolic ratio is a secondary effect of this primary transporter defect.

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data