tetrahydrocortisol glucuronide to 11beta-hydroxyandrosterone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90200267
Name: tetrahydrocortisol glucuronide
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 11beta-hydroxyandrosterone glucuronide
Metabolite Accession: GCST90200214
Name: 11beta-hydroxyandrosterone glucuronide
Hmdb Id: HMDB0010351
Super Pathway: NA
Sub Pathway: NA
Inchikey: BRPLOVMHAFXVOQ

Associated Genomic Regions

Region: rs142696888

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.415
Position:
62882727
SE (Ratio):
0.030
Effect Allele:
A
Z-score (Ratio):
-13.627
Reference Allele:
T
-log10(P):
-95.690
MAF:
0.060
Beta (Num):
-0.052
Novel Locus:
No
SE (Num):
0.029
Beta (Den):
0.363
SE (Den):
0.030
No CNV overlap
rQTL cluster:
61
Reaction Distance:
NA
Closest Genes:
SLC22A24 SLC22A10 SLC22A25 SLC22A8 SLC22A6

LLM Analysis

Numerator Metabolite Explanation:

Cortisol metabolism, Glucuronidation.6[1], 7[2]

Denominator Metabolite Explanation:

Androgen metabolism, Glucuronidation.8[1], 9[2]

Ratio Explanation:

This ratio reflects the metabolic balance between glucocorticoid (cortisol) and androgen breakdown products, potentially influenced by transporter activity or indirect genetic regulation.10[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype data was provided; therefore, a causal link between the genetic factors, the metabolite ratio, and a potential phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data