tetrahydrocortisol glucuronide to vanillylmandelate (vma)

Numerator Metabolite

Metabolite Accession: GCST90200267
Name: tetrahydrocortisol glucuronide
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of vanillylmandelate (vma)
Metabolite Accession: GCST90200309
Name: vanillylmandelate (vma)
Hmdb Id: HMDB0000291
Super Pathway: NA
Sub Pathway: NA
Inchikey: CGQCWMIAEPEHNQ

Associated Genomic Regions

Region: rs1902023

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.289
Position:
69536084
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
16.157
Reference Allele:
A
-log10(P):
-133.531
MAF:
0.477
Beta (Num):
0.103
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
-0.186
SE (Den):
0.013
No CNV overlap
rQTL cluster:
123
Reaction Distance:
NA
Closest Genes:
UGT2B15 UGT2B17 UGT2B10 TMPRSS11E UGT2A3

LLM Analysis

Numerator Metabolite Explanation:

Steroid metabolism and glucuronidation.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Catecholamine metabolism.10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

The ratio likely reflects UGT2B15-mediated cortisol clearance relative to catecholamine breakdown, offering a potential index of the balance between glucocorticoid and catecholamine pathways.6[1], 10[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered UGT2B15 activity impacts steroid hormone clearance, which can systemically influence liver function (GGT, ALP), lipid levels (TC), and red blood cell production, leading to correlated changes in MCH and MCV.14[1], 15[2], 16[3]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data