n-acetyl-2-aminoadipate to n-acetyltyrosine

Numerator Metabolite

Structure of n-acetyl-2-aminoadipate
Metabolite Accession: GCST90200268
Name: n-acetyl-2-aminoadipate
Hmdb Id: HMDB0062715
Super Pathway: NA
Sub Pathway: NA
Inchikey: FTTGAAZKBNZDCZ

Denominator Metabolite

Structure of n-acetyltyrosine
Metabolite Accession: GCST90200675
Name: n-acetyltyrosine
Hmdb Id: HMDB0000866
Super Pathway: NA
Sub Pathway: NA
Inchikey: CAHKINHBCWCHCF

Associated Genomic Regions

Region: rs12209125

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.153
Position:
25769789
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
7.513
Reference Allele:
A
-log10(P):
-30.480
MAF:
0.410
Beta (Num):
0.076
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A4 SLC17A1 HIST1H2BA HIST1H2AA SLC17A3

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): Lysine degradation.5[1], 6[2]

Denominator Metabolite Explanation:

Denominator Pathway(s): Tyrosine metabolism, protein acetylation/degradation.7[1], 8[2], 9[3]

Ratio Explanation:

Ratio Interpretation: The ratio may reflect altered transport by SLC17A4, potentially affecting urate, which shares transporter mechanisms with other organic anions, thus influencing excretion of acetylated amino acids.10[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Ratio-Phenotype Link: Altered SLC17A4 function likely modifies uric acid excretion, directly impacting serum urate levels.4[1], 12[2], 13[3] The correlated changes in red blood cell indices (MCH, MCHC, Hb) are a known secondary association with elevated uric acid.14[4], 15[5], 16[6], 17[7]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data