bilirubin degradation product, c16h18n2o5 (3)** to androstenediol (3beta,17beta) monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90200271
Name: bilirubin degradation product, c16h18n2o5 (3)**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
12
Beta (Ratio):
0.234
Position:
21343833
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
8.071
Reference Allele:
A
-log10(P):
-34.898
MAF:
0.156
Beta (Num):
0.117
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.117
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Bilirubin metabolism.10[1], 11[2], 12[3], 13[4], 14[5]

Denominator Metabolite Explanation:

Steroid biosynthesis and metabolism.15[1], 16[2], 17[3], 18[4], 19[5]

Ratio Explanation:

This ratio likely reflects OATP1B1 transport activity for its substrates, bilirubin and androstenediol monosulfate, with genetic variation impacting their relative systemic concentrations.6[1], 7[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLCO1B1 missense variant likely impairs hepatic uptake of both bilirubin and androstenediol sulfate.3[1], 6[2] Altered bilirubin levels are strongly linked to the associated hematological traits (MCH, MCV, Total Bilirubin) and have a complex relationship with coronary atherosclerosis.20[3], 21[4], 22[5]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data