3-hydroxyoctanoylcarnitine (1) to 3-hydroxydecanoate

Numerator Metabolite

Structure of 3-hydroxyoctanoylcarnitine (1)
Metabolite Accession: GCST90200272
Name: 3-hydroxyoctanoylcarnitine (1)
Hmdb Id: HMDB0061634
Super Pathway: NA
Sub Pathway: NA
Inchikey: LUBMSOHGUAAXAM

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.240
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
16.929
Reference Allele:
G
-log10(P):
-146.360
MAF:
0.318
Beta (Num):
0.030
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.210
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs35594

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.128
Position:
16148926
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-8.636
Reference Allele:
G
-log10(P):
-39.687
MAF:
0.283
Beta (Num):
-0.101
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.027
SE (Den):
0.017
No CNV overlap
rQTL cluster:
33
Reaction Distance:
NA
Closest Genes:
ABCC1 ABCC6 FOPNL NOMO3 MYH11

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis/metabolism

Ratio Explanation:

The ratio may reflect the balance between fatty acid breakdown and synthesis, potentially influenced by THEM4's thioesterase activity and ABCC1's transport function, although the direct link is unclear.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

A direct, well-established causal link between THEM4/ABCC1, the specific 3-hydroxyoctanoylcarnitine to 3-hydroxydecanoate ratio, and Mean Corpuscular Hemoglobin Concentration (MCHC) is not strongly supported by the provided information, though a general involvement of these genes in lipid metabolism, which can influence red blood cell characteristics, is plausible.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data