3-hydroxyoctanoylcarnitine (1) to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of 3-hydroxyoctanoylcarnitine (1)
Metabolite Accession: GCST90200272
Name: 3-hydroxyoctanoylcarnitine (1)
Hmdb Id: HMDB0061634
Super Pathway: NA
Sub Pathway: NA
Inchikey: LUBMSOHGUAAXAM

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs2130525

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.145
Position:
151902101
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
10.700
Reference Allele:
C
-log10(P):
-59.854
MAF:
0.392
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.120
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.

Ratio Explanation:

This ratio may reflect the balance between mitochondrial fatty acid beta-oxidation (numerator) and alternative fatty acid oxidation pathways (denominator), potentially influenced by THEM4 activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The THEM4 eQTL colocalizes with diverticular disease. Altered THEM4 expression may dysregulate fatty acid metabolism in the colon, impacting energy balance and inflammatory processes, which are implicated in the pathophysiology of diverticular disease.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data