cis-3,4-methyleneheptanoylglycine to glycine conjugate of c10h14o2 (1)*

Numerator Metabolite

Metabolite Accession: GCST90200274
Name: cis-3,4-methyleneheptanoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.156
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
9.652
Reference Allele:
C
-log10(P):
-49.086
MAF:
0.209
Beta (Num):
0.136
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.021
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs111598382

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.380
Position:
96709877
SE (Ratio):
0.027
Effect Allele:
A
Z-score (Ratio):
-14.096
Reference Allele:
G
-log10(P):
-102.220
MAF:
0.065
Beta (Num):
0.007
Novel Locus:
No
SE (Num):
0.031
Beta (Den):
0.387
SE (Den):
0.032
No CNV overlap
rQTL cluster:
72
Reaction Distance:
NA
Closest Genes:
CYP2C9 CYP2C8 CYP2C19 CYP2C18 C10orf129

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): Fatty acid metabolism.5[1]

Denominator Metabolite Explanation:

Denominator Pathway(s): Xenobiotic metabolism, Glycine metabolism.6[1], 7[2]

Ratio Explanation:

Ratio Interpretation: An increased ratio of cis-3,4-methyleneheptanoylglycine to another glycine conjugate suggests altered fatty acid metabolism, potentially due to reduced FAAH activity impacting the relative levels of different acyl-glycines.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Gene-centric: FAAH inhibition has been shown to protect against NSAID-induced gastric ulcers.8[1], 9[2] Altered FAAH activity, due to genetic variation, could influence susceptibility to gastroduodenal ulcers by modulating inflammatory pathways influenced by fatty acid amides.

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data