3-hydroxyoctanoylcarnitine (2) to Hexanoylcarnitine

Numerator Metabolite

Structure of 3-hydroxyoctanoylcarnitine (2)
Metabolite Accession: GCST90200278
Name: 3-hydroxyoctanoylcarnitine (2)
Hmdb Id: HMDB0061634
Super Pathway: NA
Sub Pathway: NA
Inchikey: LUBMSOHGUAAXAM

Denominator Metabolite

Structure of hexanoylcarnitine (c6)
Metabolite Accession: GCST90199668
Name: hexanoylcarnitine (c6)
Hmdb Id: HMDB0000756
Super Pathway: NA
Sub Pathway: NA
Inchikey: VVPRQWTYSNDTEA

Associated Genomic Regions

Region: rs17843919

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.117
Position:
159638966
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
7.517
Reference Allele:
A
-log10(P):
-30.510
MAF:
0.296
Beta (Num):
0.037
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.079
SE (Den):
0.016
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
PPID ETFDH C4orf46 FNIP2 RXFP1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

This ratio reflects the activity of enzymes in the fatty acid oxidation pathway downstream of the reaction catalyzed by ACADM.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data