3-hydroxyoctanoylcarnitine (2) to myristoleoylcarnitine (c14:1)*

Numerator Metabolite

Structure of 3-hydroxyoctanoylcarnitine (2)
Metabolite Accession: GCST90200278
Name: 3-hydroxyoctanoylcarnitine (2)
Hmdb Id: HMDB0061634
Super Pathway: NA
Sub Pathway: NA
Inchikey: LUBMSOHGUAAXAM

Denominator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Associated Genomic Regions

Region: rs60782127

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.470
Position:
16142079
SE (Ratio):
0.053
Effect Allele:
T
Z-score (Ratio):
-8.841
Reference Allele:
G
-log10(P):
-41.498
MAF:
0.011
Beta (Num):
-0.471
Novel Locus:
Yes ✔️
SE (Num):
0.073
Beta (Den):
-0.001
SE (Den):
0.071
No CNV overlap
rQTL cluster:
173
Reaction Distance:
NA
Closest Genes:
ABCC1 ABCC6 FOPNL NOMO3 MYH11

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.3[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Ratio Explanation:

none

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

The ABCC1 variant may alter its transport function, impacting cellular homeostasis and energy metabolism, as reflected by the acylcarnitine ratio. This systemic metabolic alteration could plausibly be one of many factors influencing complex growth processes that determine final height.6[1]

Phenotype Driver:

Gene-centric:ABCC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data