3-hydroxyoctanoylcarnitine (2) to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of 3-hydroxyoctanoylcarnitine (2)
Metabolite Accession: GCST90200278
Name: 3-hydroxyoctanoylcarnitine (2)
Hmdb Id: HMDB0061634
Super Pathway: NA
Sub Pathway: NA
Inchikey: LUBMSOHGUAAXAM

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs60782127

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.522
Position:
16142079
SE (Ratio):
0.060
Effect Allele:
T
Z-score (Ratio):
-8.661
Reference Allele:
G
-log10(P):
-39.902
MAF:
0.011
Beta (Num):
-0.471
Novel Locus:
Yes ✔️
SE (Num):
0.073
Beta (Den):
0.051
SE (Den):
0.069
No CNV overlap
rQTL cluster:
173
Reaction Distance:
NA
Closest Genes:
ABCC1 ABCC6 FOPNL NOMO3 MYH11

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.5[1], 4[2], 6[3]

Ratio Explanation:

The ratio of 3-hydroxyoctanoylcarnitine to palmitoleoylcarnitine may reflect altered fatty acid oxidation, potentially influenced by the transport activity of ABCC1 on acylcarnitine species.1[1], 7[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

A missense variant in ABCC1, a transporter, is associated with height. ABCC1 may influence cellular processes that impact growth by transporting signaling molecules or metabolites, including acylcarnitines, although a direct link between this specific ratio and height via ABCC1 is not established.1[1], 9[2]

Phenotype Driver:

Gene-centric:ABCC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data