picolinate to 4-hydroxyphenylacetoylcarnitine

Numerator Metabolite

Structure of picolinate
Metabolite Accession: GCST90200282
Name: picolinate
Hmdb Id: HMDB0002243
Super Pathway: NA
Sub Pathway: NA
Inchikey: SIOXPEMLGUPBBT

Denominator Metabolite

Metabolite Accession: GCST90200027
Name: 4-hydroxyphenylacetoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs77863699

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.862
Position:
20563528
SE (Ratio):
0.073
Effect Allele:
C
Z-score (Ratio):
11.819
Reference Allele:
T
-log10(P):
-72.547
MAF:
0.026
Beta (Num):
0.539
Novel Locus:
No
SE (Num):
0.052
Beta (Den):
-0.323
SE (Den):
0.053
No CNV overlap
rQTL cluster:
28
Reaction Distance:
NA
Closest Genes:
ACSM2B ACSM3 AC137056.1 ACSM2A ACSM1

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Tyrosine metabolism, carnitine conjugation.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio may reflect altered ACSM2B activity, which has a higher affinity for benzoate than phenylacetate, potentially affecting the metabolism of their respective upstream precursors.9[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype was associated through colocalization or Mendelian randomization, so a direct link between the ratio and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data