erucate (22:1n9) to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of erucate (22:1n9)
Metabolite Accession: GCST90200284
Name: erucate (22:1n9)
Hmdb Id: HMDB0002068
Super Pathway: NA
Sub Pathway: NA
Inchikey: DPUOLQHDNGRHBS

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.152
Position:
15979744
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
8.260
Reference Allele:
C
-log10(P):
-36.466
MAF:
0.296
Beta (Num):
0.056
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.095
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis; very long-chain fatty acid metabolism.8[1]

Denominator Metabolite Explanation:

Fatty acid omega oxidation; dicarboxylic acid metabolism.9[1], 10[2]

Ratio Explanation:

An elevated ratio of erucate to hexadecanedioate may reflect decreased omega-oxidation of erucate, a very long-chain fatty acid, by the less active CYP4F2 enzyme.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The *CYP4F2* V433M variant reduces the enzyme's activity, potentially leading to increased levels of its substrate, erucate.1[1], 2[2], 3[3] Elevated erucate levels have been associated with an increased risk of coronary heart disease.11[4], 12[5], 13[6], 14[7] This suggests a gene-centric mechanism where impaired fatty acid metabolism by CYP4F2 contributes to the phenotype.

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data