n-acetylleucine to 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)

Numerator Metabolite

Structure of n-acetylleucine
Metabolite Accession: GCST90200288
Name: n-acetylleucine
Hmdb Id: HMDB0011756
Super Pathway: NA
Sub Pathway: NA
Inchikey: WXNXCEHXYPACJF

Denominator Metabolite

Structure of 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Metabolite Accession: GCST90199712
Name: 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Hmdb Id: HMDB0061112
Super Pathway: NA
Sub Pathway: NA
Inchikey: WMCQWXZMVIETAO

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.192
Position:
25802083
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-9.172
Reference Allele:
T
-log10(P):
-44.512
MAF:
0.444
Beta (Num):
-0.090
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.102
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Leucine metabolism, protein acetylation.4[1]

Denominator Metabolite Explanation:

Furanoid fatty acid metabolism, uremic toxin pathway.5[1], 6[2]

Ratio Explanation:

The ratio may reflect competitive transport or differential clearance of n-acetylleucine and CMPF, both organic anions, by the SLC17A4 transporter in the kidney.3[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variation in the SLC17A4 transporter gene likely alters renal handling of uric acid and other organic anions like CMPF.3[1], 8[2] This impacts serum urate and creatinine, key markers of renal function which in turn can influence hematological indices like MCHC and hematocrit.9[3], 10[4]

Phenotype Driver:

Gene-centric:[SLC17A4]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data