n-acetylleucine to phenylacetylglutamate

Numerator Metabolite

Structure of n-acetylleucine
Metabolite Accession: GCST90200288
Name: n-acetylleucine
Hmdb Id: HMDB0011756
Super Pathway: NA
Sub Pathway: NA
Inchikey: WXNXCEHXYPACJF

Denominator Metabolite

Structure of phenylacetylglutamate
Metabolite Accession: GCST90200069
Name: phenylacetylglutamate
Hmdb Id: HMDB0059772
Super Pathway: NA
Sub Pathway: NA
Inchikey: PTSRBZOZSRJCKX

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.251
Position:
25794431
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-11.249
Reference Allele:
G
-log10(P):
-65.926
MAF:
0.444
Beta (Num):
-0.089
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.161
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Leucine metabolism, protein degradation.4[1]

Denominator Metabolite Explanation:

Phenylalanine metabolism, gut microbiome.5[1], 6[2]

Ratio Explanation:

none

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant may alter transport of organic anions. The associated phenotypes, particularly those related to red blood cells (MCHC, MCH, Ht, Hb, MCV) and urate, suggest a link between SLC17A4's role as a urate and thyroid hormone transporter and hematopoiesis.2[1], 7[2], 8[3], 9[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data