n-acetylleucine to caffeic acid sulfate

Numerator Metabolite

Structure of n-acetylleucine
Metabolite Accession: GCST90200288
Name: n-acetylleucine
Hmdb Id: HMDB0011756
Super Pathway: NA
Sub Pathway: NA
Inchikey: WXNXCEHXYPACJF

Denominator Metabolite

Structure of caffeic acid sulfate
Metabolite Accession: GCST90200093
Name: caffeic acid sulfate
Hmdb Id: HMDB0041708
Super Pathway: NA
Sub Pathway: NA
Inchikey: SNVAIAITQIIEMQ

Associated Genomic Regions

Region: rs1183200

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.171
Position:
25818646
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
-7.999
Reference Allele:
C
-log10(P):
-34.314
MAF:
0.444
Beta (Num):
-0.091
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.080
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Leucine metabolism, Protein acetylation.4[1]

Denominator Metabolite Explanation:

Phenylpropanoid metabolism, Sulfation detoxification.5[1], 6[2]

Ratio Explanation:

The ratio may reflect altered transport of urate or other organic anions by SLC17A4, though a direct link to both metabolites is not established.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SLC17A4 gene, a known urate transporter, likely influences serum uric acid levels.7[1] Altered SLC17A4 function could impact uric acid excretion, a phenotype observed in the BioBank Japan data, and may also be associated with observed hematological traits through less defined mechanisms.8[2]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data